What severe bone impairment is of genetic origin and affects collagen formation?

Osteogenesis imperfecta, often referred to as "brittle bone disease," is a severe condition characterized by a genetic defect that affects the production of collagen, a crucial protein that provides strength and structure to bones. In individuals with osteogenesis imperfecta, the body either produces insufficient collagen or forms collagen that is structurally abnormal, which leads to bones that are fragile and more prone to fractures. This genetic origin differentiates it from other conditions like osteoporosis or Paget's disease, which may be influenced more by environmental factors, hormonal changes, or age rather than a direct genetic defect in collagen synthesis. Understanding the specific genetic basis of osteogenesis imperfecta is central to recognizing its clinical implications and managing the condition effectively.